In vitro drug resistance and prognostic impact of p16INK4A /P15INK4B deletions in childhood T-cell acute lymphoblastic leukaemia
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چکیده
منابع مشابه
In vitro drug resistance profiles of adult versus childhood acute lymphoblastic leukaemia.
The difference in the current cure rates between adult and childhood acute lymphoblastic leukaemia (ALL) may be caused by differences in drug resistance. Earlier studies showed that in vitro cellular drug resistance is a strong independent adverse risk factor in childhood ALL. Knowledge about cellular drug resistance in adult ALL is still limited. The present study compared the in vitro drug re...
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1 Fargeas CA, Corbeil D, Huttner WB. AC133 antigen, CD133, prominin-1, prominin-2, etc.: prominin family gene products in need of a rational nomenclature. Stem Cells 2003; 21: 506–508. 2 Kuci S, Wessels JT, Buhring HJ, Schilbach K, Schumm M, Seitz G et al. Identification of a novel class of human adherent CD34-stem cells that give rise to SCID-repopulating cells. Blood 2003; 101: 869–876. 3 Ric...
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cord blood), women 25 to 32 years old (young women group), and women more than 75 years old (elderly women). The frequency of skewed X inactivation in polymorphonuclear cells (PMNs) increased with age: in fact, a cleavage ratio of at least 3.0 was found in 3 of 36 cord blood samples, 5 of 30 young women, and 14 of 31 elderly women. The inactivation patterns found in T lymphocytes were significa...
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Background: Treatment of pediatric T-cell acute lymphoblastic leukemia (T-ALL) has improved, but there is a considerable fraction of patients experiencing a poor outcome. There is a need for better prognostic markers and aberrant DNA methylation is a candidate in other malignancies, but its potential prognostic significance in T-ALL is hitherto undecided. Design and Methods: Genome wide promote...
متن کاملMorphological heterogeneity in childhood B cell acute lymphoblastic leukaemia.
Considerable heterogeneity of lymphoblast morphology in childhood B cell acute lymphoblastic leukaemia has been observed. One case showed unusual monocytic features and emphasised the need for marker studies in the accurate definition of acute lymphoblastic leukaemia phenotypes. B cell acute lymphoblastic leukaemia is rare but may have been previously underestimated by morphological misinterpre...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2001
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2001.02586.x